Prolactin reduces arthritis inflammation

Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health. Researchers have identified prolactin as a potential treatment for inflammatory joint disease. Prolactin treatment prevented chondrocyte death and associated cartilage degradation. In a model of inflammatory arthritis, prolactin treatment reduced inflammation, bone erosion, joint swelling, and pain. This study indicates that prolactin therapy has the potential to relieve many symptoms associated with rheumatoid arthritis and other inflammatory-related diseases.

View this article at: http://www.jci.org/articles/view/69485?key=2d78378940de873cad9b